2026
Hepatocyte FAM210A deficiency disrupts mitochondrial function and triggers juvenile steatosis with compensatory repair in adulthood
Yubo Wang, Leah Chu, Yumei Zhou, Zihao Jin, Kyoungrae Kim, Katie Heiden, Miguel A Gutierrez-Monreal, Junxiao Ren, Yufen Li, Zhiyong Cheng, Kari B Basso, Karyn A Esser, Terence E Ryan, Feng Yue#. Communications Biology (under revision). (#Corresponding)
A myocyte-enriched long non-coding RNA NRMLncR enhances myogenesis in mouse
Yufen Li, Yumei Zhou, Qing Ying Li, Justine Arrington, Mostafa F Abdelhai, Yubo Wang, Junxiao Ren, Yung-Yu Cheng, Mingyi Xie, W Andy Tao, Shihuan Kuang, Feng Yue#. The FASEB Journal (Accepted). (#Corresponding)
Moderate iron restriction improves metabolism via epigenetic regulation of GDF15
Jinying Yang, Limin Shi, Anna L Cubito, Akshaya Govarthanan, Jian S Sabripour, Karen Scott, Annette de Kloet, Feng Yue, Bin Liu, Larissa J Strath, Eric Krause, James F Collins, Zhiyong Cheng. The Journal of Nutritional Biochemistry 10.1016/j.jnutbio.2026.110448 (2026).
Interaction of Sepsis, Disuse, and Aging on Skeletal Muscle Function and Remodeling in Male and Female Mice
Diana C Muller, Franccesco P Boeno, Gisienne Reis, Armina Azam, Malaica Ashley, Yumei Zhou, Feng Yue, Terence E Ryan, Philip A Efron, Orlando Laitano. Acta Physiologica https://doi.org/10.1111/apha.70195 (2026).
Chondrolectin regulates the sublaminar localization and regenerative function of muscle satellite cells in mice
Lijie Gu, Kun Ho Kim, Xiyue Chen, Stephanie N Oprescu, Yufen Li, Junxiao Ren, Shihuan Kuang, Feng Yue#. iScience https://doi.org/10.1016/j.isci.2026.115703 (2026). (#Corresponding)
ASB5 is a specific marker for muscle satellite cells but dispensable for skeletal muscle development and regeneration
Muhammad Asif, Stephanie N Oprescu, Renjie Shang, Zheng Zhang, Feng Yue, Pengpeng Bi, Shihuan Kuang. Skeletal Muscle https://doi.org/10.1186/s13395-025-00409-y (2026).
Heat shock suppresses the innate immune response of bovine endometrial epithelial cells
Arslan Tariq, Masroor Sagheer, Zachary K Seekford, Junxiao Ren, Feng Yue, John J Bromfield. Reproduction and Fertility https://doi.org/10.1530/RAF-25-0213 (2026).
2025
Mitochondrial fatty acid oxidation regulates adult muscle stem cell function through modulating metabolic flux and protein acetylation
Feng Yue*#, Lijie Gu*, Jiamin Qiu*, Stephanie N. Oprescu, Linda M. Beckett, Jessica M. Ellis, Shawn S. Donkin, Shihuan Kuang#. The EMBO Journal https://doi.org/10.1038/s44318-025-00397-1 (2025). (*Co-first, #Co-corresponding)
Ablation of FAM210A in brown adipocytes of mice exacerbates high fat diet induced metabolic dysfunction
Jiamin Qiu, Mennatallah A Khedr, Meijin Pan, Christina R. Ferreira, Jingjuan Chen, Madigan M Snyder, Kolapo M Ajuwon, Feng Yue#, Shihuan Kuang#. Diabetes db240294, https://doi.org/10.2337/db24-0294 (2025). (#Co-corresponding)
Multiomics identifies unique modulators of calf muscle pathophysiology in peripheral artery disease and chronic kidney disease
Kyoungrae Kim, Trace Thome, Caroline G Pass, Lauren Stone, Nicholas Vugman, Victoria Palzkill, Qingping Yang, Kerri O’Malley, Erik Michael Anderson, Brian Fazzone, Feng Yue, Scott A Berceli, Salvatore T Scali, Terence E Ryan. Circulation Research https://doi.org/10.1161/CIRCRESAHA.124.325642 (2025).
2024
Overexpression of CPT1A disrupts the maintenance and regenerative function of muscle stem cells
Jiamin Qiu*, Feng Yue*#, Kun Ho Kim, Xiyue Chen, Mennatallah A. Khedr, Jingjuan Chen, Lijie Gu, Junxiao Ren, Christina R. Ferreira, Jessica Ellis, Shihuan Kuang#. The FASEB Journal 38: e70071, doi:10.1096/fj.202400947R (2024). (*Co-first, #Co-corresponding)
FAM210A: An emerging regulator of mitochondrial homeostasis
Yubo Wang, Feng Yue. BioEssays 46, e2400090, http://doi.org/10.1002/bies.202400090 (2024).
Loss of FoxO1 activates an alternate mechanism of mitochondrial quality control for healthy adipose browning
Limin Shi, Jinying Yang, Zhipeng Tao, Louise Zheng, Tyler F Bui, Ramon L Alonso, Feng Yue, Zhiyong Cheng. Clinical Science 138 (6), 371-385 (2024).
Effects of ruminal LPS exposure on primary bovine ruminal epithelial cells
Efstathios Sarmikasoglou, Leah Chu, Feng Yue, Antonio Faciola. Journal of Dairy Science 107 (2), 1244-1262 (2024).
2023
FAM210A mediates an inter-organelle crosstalk essential for protein synthesis and muscle growth in mouse
Jingjuan Chen*, Feng Yue*#, Kun Ho Kim, Peipei Zhu, Jiamin Qiu, W. Andy Tao, Shihuan Kuang#. bioRxiv, 2023. (*Co-first, #Co-corresponding)
PRMT5 mediates FoxO1 methylation and subcellular localization to regulate lipophagy in myogenic progenitors
Kun Ho Kim, Stephanie Nicole Oprescu, Madigan Strange, Aran Kim, Zhihao Jia, Feng Yue, Shihuan Kuang. Cell Reports, 42(11) (2023).
FAM210A is essential for cold-induced mitochondrial remodeling in brown adipocytes
Jiamin Qiu*, Feng Yue*#, Peipei Zhu, Jingjuan Chen, Fan Xu, Lijia Zhang, Kun Ho Kim, Madigan Strange, Nanjian Luo, Hao-wei Xu, Fang Huang, W. Andy Tao, Shihuan Kuang#. Nature Communications, 14: 6344 (2023). (*Co-first, #Co-corresponding)
Sox11 is enriched in myogenic progenitors but dispensable for development and regeneration of skeletal muscle
Stephanie Nicole Oprescu, Nick Baumann, Xiyue Chen, Qiang Sun, Yu Zhao, Feng Yue, Huating Wang, Shihuan Kuang. Skeletal Muscle 13;13(1): 15 (2023).
Single Nuclei RNA Sequencing of the Gastrocnemius Muscle in Peripheral Artery Disease
Caroline G Pass, Victoria Palzkill, Jianna Tan, Kyoungrae Kim, Trace Thome, Qingping Yang, Brian Fazzone, Scott T Robinson, Kerri O’Malley, Feng Yue, Salvatore T Scali, Scott A Berceli, Terence E Ryan. Circulation Research 133 (10), 791-809 (2023).
PRMT5 links lipid metabolism to contractile function of skeletal muscles
Kun Ho Kim, Zhihao Jia, Madigan Strange, Jingjuan Chen, Jiamin Qiu, Stephanie Oprescu, Xiyue Chen, Sabriya Syed, Feng Yue, Bruno Roseguini, Anthony Imbalzano, Changdeng Hu, and Shihuan Kuang. EMBO Reports 24 (8), e57306 (2023).
Chronic activation of the aryl hydrocarbon receptor in muscle exacerbates ischemic pathology in chronic kidney disease
Nicholas Balestrieri, Victoria Palzkill, Caroline Pass, Jianna Tan, Zachary R Salyers, Chatick Moparthy, Ania Murillo, Kyoungrae Kim, Trace Thome, Qingping Yang, Kerri A O’Malley, Scott A Berceli, Feng Yue, Salvatore T Scali, Leonardo F Ferreira, Terence E Ryan. Circulation Research 133, 158–176 (2023).
IGF-1 therapy improves muscle size and function in experimental peripheral arterial disease
Gengfu Dong, Chatick Moparthy, Trace Thome, Kyoungrae Kim, Feng Yue, Terence E Ryan. JACC: Basic to Translational Science (2023).
Multimodal high-resolution nano-DESI MSI and immunofluorescence imaging reveal molecular signatures of skeletal muscle fiber types
Daisy Unsihuay, Hang Hu, Jiamin Qiu, Alessandra Latorre, Manxi Yang, Feng Yue, Ruichuan Yin, Shihuan Kuang, Julia Laskin. Chem. Sci. 14, 4070-4082 (2023).
2022
Labeling and analyzing lipid droplets in mouse muscle stem cells
Chen, J., Yue, F. & Kuang, S. STAR protocols 3 (4), 101849 (2022).
Chchd10 is dispensable for myogenesis but critical for adipose browning
Xia, W., Qiu, J., Peng, Y., Snyder, M.M., Gu, L., Huang, K., Luo, N., Yue, F. & Kuang, S. Cell Regeneration 11 (1), 1-15 (2022).
ACSS3 in brown fat drives propionate catabolism and its deficiency leads to autophagy and systemic metabolic dysfunction
Jia, Z., Chen, X., Chen, J., Zhang, L., Oprescu, S.N., Luo, N., Xiong, Y., Yue, F. & Kuang, S. Clinical and translational medicine 12 (2), e665 (2022).
Lipid droplet dynamics regulate adult muscle stem cell fate
Yue, F.#, Oprescu, S.N., Qiu, J., Gu, L., Zhang, L., Chen, J., Narayanan, N., Deng M. & Kuang, S#. Cell Reports 38, 110267 (2022). (#Co-corresponding)
Before UF
2021
LETMD1 is required for mitochondrial structure and thermogenic function of brown adipocytes
Snyder, M.M.*, Yue, F.*#, Zhang, L., Shang, R., Qiu, J., Chen, J., Kim, K.H., Peng, Y., Oprescu, S.N., Donkin, S.S., Bi, P. & Kuang, S#. The FASEB Journal 35, e21965 (2021). (*Co-first, #Co-corresponding)
PTEN inhibition ameliorates muscle degeneration and improves muscle function in a mouse model of Duchenne muscular dystrophy
Yue, F.*#, Song, C.*, Huang, D., Narayanan, N., Qiu, J., Jia, Z., Yuan, Z., Oprescu, S.N., Roseguini, B.T., Deng, M. & Kuang, S#. Molecular Therapy 29, 132-148 (2021). (*Co-first, #Co-corresponding)
Phosphatase orphan 1 inhibits myoblast proliferation and promotes myogenic differentiation
Peng, Y.*, Yue, F.*, Chen, J., Xia, W., Huang, K., Yang, G. & Kuang, S. The FASEB Journal 35, e21154 (2021). (*Co-first)
Reduced electron transport chain complex I protein abundance and function in Mfn2‐deficient myogenic progenitors lead to oxidative stress and mitochondria swelling
Luo, N., Yue, F., Jia, Z., Chen, J., Deng, Q., Zhao, Y. & Kuang, S. The FASEB Journal 35, e21426 (2021).
2020
Protein arginine methyltransferase PRMT5 regulates fatty acid metabolism and lipid droplet biogenesis in white adipose tissues
Jia, Z.*, Yue, F.*, Chen, X., Narayanan, N., Qiu, J., Syed, S.A., Imbalzano, A.N., Deng, M., Yu, P., Hu, C. & Kuang, S. Advanced Science 7, 2002602 (2020). (*Co-first)
Single-Cell Isolation from Regenerating Murine Muscles for RNA-Sequencing Analysis
Oprescu, S.N., Yue, F. & Kuang, S. STAR Protocols, 100051 (2020).
Temporal dynamics and heterogeneity of cell populations during skeletal muscle regeneration
Oprescu, S.N., Yue, F., Qiu, J., Brito, L.F. & Kuang, S. Iscience, 100993 (2020).
Polymeric nanoparticles functionalized with muscle-homing peptides for targeted delivery of phosphatase and tensin homolog inhibitor to skeletal muscle
Huang, D., Yue, F#., Qiu, J., Deng, M. & Kuang, S#. Acta Biomaterialia, 118, 196-206 (2020). (#Co-corresponding)
2019
Methyltransferase‐like 21e inhibits 26S proteasome activity to facilitate hypertrophy of type IIb myofibers
Wang, C., Zhang, B., Ratliff, A.C., Arlington, J., Chen, J., Xiong, Y., Yue, F., Nie, Y., Hu, K., Jin, W. & Kuang, S. The FASEB Journal 33, 9672-9684 (2019).
Methyltransferase-like 21c methylates and stabilizes the heat shock protein Hspa8 in type I myofibers in mice
Wang, C., Arrington, J., Ratliff, A.C., Chen, J., Horton, H.E., Nie, Y., Yue, F., Hrycyna, C.A., Tao, W.A. & Kuang, S. Journal of Biological Chemistry 294, 13718-13728 (2019).
Advanced glycation end-products suppress mitochondrial function and proliferative capacity of achilles tendon-derived fibroblasts
Patel, S.H., Yue, F., Saw, S.K., Foguth, R., Cannon, J.R., Shannahan, J.H., Kuang, S., Sabbaghi, A. & Carroll, C.C. Scientific reports 9, 1-17 (2019).
A requirement of Polo-like kinase 1 in murine embryonic myogenesis and adult muscle regeneration
Jia, Z., Nie, Y., Yue, F., Kong, Y., Gu, L., Gavin, T.P., Liu, X. & Kuang, S. Elife 8, e47097 (2019).
2018
A novel brown adipocyte-enriched long non-coding RNA that is required for brown adipocyte differentiation and sufficient to drive thermogenic gene program in white adipocytes
Xiong, Y.*, Yue, F.*, Jia, Z., Gao, Y., Jin, W., Hu, K., Zhang, Y., Zhu, D., Yang, G. & Kuang, S.Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids 1863, 409-419 (2018). (*Co-first)
Microarray, IPA and GSEA Analysis in Mice Models
Oprescu, S.N., Horzmann, K.A., Yue, F., Freeman, J.L. & Kuang, S. Bio-protocol 8 (2018).
2017
Pten is necessary for the quiescence and maintenance of adult muscle stem cells
Yue, F., Bi, P., Wang, C., Shan, T., Nie, Y., Ratliff, T.L., Gavin, T.P. & Kuang, S. Nature communications 8, 1-13 (2017).
Peripheral neuropathy and hindlimb paralysis in a mouse model of adipocyte-specific knockout of Lkb1
Xiong, Y., Page, J.C., Narayanan, N., Wang, C., Jia, Z., Yue, F., Shi, X., Jin, W., Hu, K., Deng, M. & Kuang, S. EBioMedicine 24, 127-136 (2017).
Muscle histology characterization using H&E staining and muscle fiber type classification using immunofluorescence staining
Wang, C., Yue, F. & Kuang, S. Bio-protocol 7 (2017).
Ascl2 inhibits myogenesis by antagonizing the transcriptional activity of myogenic regulatory factors
Wang, C., Wang, M., Arrington, J., Shan, T., Yue, F., Nie, Y., Tao, W.A. & Kuang, S. Development 144, 235-247 (2017).
Loss of MyoD promotes fate transdifferentiation of myoblasts into brown adipocytes
Wang, C., Liu, W., Nie, Y., Qaher, M., Horton, H.E., Yue, F., Asakura, A. & Kuang, S. EBioMedicine 16, 212-223 (2017).
Dibenzazepine-loaded nanoparticles induce local browning of white adipose tissue to counteract obesity
Jiang, C., Cano-Vega, M.A., Yue, F., Kuang, L., Narayanan, N., Uzunalli, G., Merkel, M.P., Kuang, S. & Deng, M. Molecular Therapy 25, 1718-1729 (2017).
2016
Conditional loss of Pten in myogenic progenitors leads to postnatal skeletal muscle hypertrophy but age-dependent exhaustion of satellite cells
Yue, F., Bi, P., Wang, C., Li, J., Liu, X. & Kuang, S. Cell reports 17, 2340-2353 (2016).
Lkb1 controls brown adipose tissue growth and thermogenesis by regulating the intracellular localization of CRTC3
Shan, T., Xiong, Y., Zhang, P., Li, Z., Jiang, Q., Bi, P., Yue, F., Yang, G., Wang, Y., Liu, X. & Kuang, S. Nature Communications 7 (2016).
Impaired exercise tolerance, mitochondrial biogenesis, and muscle fiber maintenance in miR-133a–deficient mice
Nie, Y., Sato, Y., Wang, C., Yue, F., Kuang, S. & Gavin, T.P. The FASEB Journal, fj. 201600529R (2016).
The brain expressed x-linked gene 1 (Bex1) regulates myoblast fusion
Jiang, C., Wang, J.-H., Yue, F. & Kuang, S. Developmental biology 409, 16-25 (2016).
Stage-specific effects of Notch activation during skeletal myogenesis
Bi, P.*, Yue, F.*, Sato, Y., Wirbisky, S., Liu, W., Shan, T., Wen, Y., Zhou, D., Freeman, J. & Kuang, S. eLife 5, e17355 (2016). (*Co-first)
Notch activation drives adipocyte dedifferentiation and tumorigenic transformation in mice
Bi, P., Yue, F., Karki, A., Castro, B., Wirbisky, S.E., Wang, C., Durkes, A., Elzey, B.D., Andrisani, O.M., Bidwell, C.A. & Kuang, S. The Journal of Experimental Medicine 213, 2019-2037 (2016).
2015
Biodegradable polymeric microsphere-based drug delivery for inductive browning of fat
Jiang, C., Kuang, L., Merkel, M.P., Yue, F., Cano-Vega, M.A., Narayanan, N., Kuang, S. & Deng, M. Frontiers in endocrinology 6, 169 (2015).
2014
Lkb1 is indispensable for skeletal muscle development, regeneration, and satellite cell homeostasis
Shan, T., Zhang, P., Liang, X., Bi, P., Yue, F. & Kuang, S. Stem Cells 32, 2893-2907 (2014).
Inhibition of Notch signaling promotes browning of white adipose tissue and ameliorates obesity
Bi, P., Shan, T., Liu, W., Yue, F., Yang, X., Liang, X.-R., Wang, J., Li, J., Carlesso, N., Liu, X. & Kuang, S. Nature medicine 20, 911-918 (2014).
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